natural supplements for histamine intolerance

Best Histamine Intolerance Supplements for Healing

In Antihistamine Addiction, Natural Allergy Supplements by Anthony42 Comments

natural histamine intolerance supplements

Certain Probiotic Strains Can Cause Histamine Intolerance

Histamine intolerance is a condition that describes high amounts of histamine in your blood. This may happen to you are eating a high-histamine diet or are experiencing reactions from food or environmental allergies. A lot of people learn about having this condition and find much success in taking histamine intolerance supplements that help improve their health and well-being.

In this post for you, I will discuss how certain probiotics can cause histamine intolerance and which supplements are actually healthy for treating this condition.

A few factors may lead to elevated amounts of histamine in the body and one of them may likely be genetics. In some people, specific enzymes that degrade histamine like N-methyl transferase and a mucus enzyme called diamine oxidase.

Deficiencies in this enzyme is likely the root cause of histamine intolerance and the symptoms that you experience with it. In healthy people, histamine levels are quickly brought down at the chemical is broken down by the enzyme. In some, histamine lingers in the blood and causes uncomfortable symptoms.

But certain histamine intolerance supplements can definitely treat the condition naturally and effectively. Many others and I would definitely tell you that once you learn about histamine intolerance and you treat it, you can feel and look so much better.

Histamine Intolerance Supplements to AVOID AT ALL COSTS

First of all, I should feel obligated to tell my viewers something really useful for treating histamine intolerance.

The gut has a huge connection to this condition and your intestinal flora has a huge part in it. In fact, some bacteria labeled as healthy probiotics can raise histamine levels in the body.

Lactobacillus bacteria can raise histamine levels in the body

For some people that suffer from histamine intolerance symptoms, this strain of probiotics can actually produce histamine as a natural form of protection. Lactobacillus can actually be considered an animal product because it is formed in milk.

If you are having problems with histamine intolerance, I’d strongly advise you to stop taking any probiotics that contain these probiotics. This is especially if you think that you have adverse reactions to taking them.

This was the case for me. I always thought that taking probiotics was healthy and that Lactobacillus helped my body. Perhaps too much of this bacteria is a very bad thing? More research is always needed.

Effective histamine intolerance supplements that work

These supplements have worked for me and many of you guys. I’m sure they will work for you, but everyone is different and you must find out the root cause of your histamine intolerance.

Hands-down best supplement for histamine intolerance is diamine oxidase

This is the stuff that your body is deficient in, which is causing your histamine intolerance at the source. If you take it, you would be treating the root cause of the condition.

Taking a supplement form of what you are deficient in is exactly what you need.

It is possible that genetics may be to blame for your low diamine oxidase levels, so these people should definitely take a supplement in particular. The best DAO supplement that I could find is this one on Amazon.

DAO for histamine intolerance

This is the best DAO supplement that I could find! Also a great price for the quality.


If you start taking diamine oxidase as a histamine intolerance natural treatment, you can allow your body precious time to heal and restore its natural function of diamine oxidase so that you won’t need to supplement anymore. This is exactly the OPPOSITE of taking an OTC antihistamine, which are all physically addictive and require you to buy more.

And they are very expensive at times. Not to mention that pharma companies likely design these drugs to be addictive so you buy more. The human market can be sketchy, but I usually trust supplements that have been used by our human ancestors for thousands of years.

Histamine intolerance probiotics

That being said about how too much Lactobacillus can be bad for you, definitely start incorporating a quality probiotic supplement that doesn’t have that strain in there.

In fact, Bifidobacterium have been proven in research to benefit histamine intolerance sufferers much more effectively. A supplement with this family strain as a foundation helped high histamine levels tremendously.

histamine intolerance probiotics

This well-reviewed probiotic doesn’t have Lactobacillus, so it would be great for you if you have histamine intolerance symptoms.

This probiotic for histamine intolerance did wonders for my health. I feel much more clear and as if my digestion were much smoother after taking this supplement. Many allergy sufferers review it highly around the world and support its claim to be well-researched and developed.

Organic quercetin is great for lowering histamine levels

This natural flavanol can do wonders for your health. Quercetin has excellent benefits for allergies and high histamine levels because it is a natural antihistamine.

An obvious solution to excess histamine levels would be to take an antihistamine. These types of compounds have a wondrous ability to lower histamine levels in the blood. However, taking an antihistamine from a natural compound, rather than an OTC drug, because it can be naturally processed and assimilated through your body as if it were food.


quercetin bromelain

This quercetin antihistamine is derived from vegetables and works by preventing the release of histamine. It also incorporates Bromelain, which is an enzyme that breaks down lingering amounts of histamine that remain. Click here to check the best price I could find.

The Food and Drug Administration and World Health Organization have stated that quercetin is a harmless and possibly effective supplement.

Personally, this natural antihistamine has changed my severe allergies forever. I no longer need addictive OTC drugs to mask my allergy symptoms for a short while. If you have histamine intolerance, its anti-inflammatory and antihistamine effects can do great things for you.


Milk thistle is an excellent natural antihistamine

The compound in milk thistle called silibinin has been shown in research to prevent the release of histamine and inflammatory cytokines that cause allergies.

This natural supplement targets the mast cells, the immune systems pro-inflammatory cells and blocks the release of inflammatory chemicals that cause allergies.

Most notably, milk thistle as a histamine intolerance supplement can be extremely effective due to its unique immune health benefits. In trials, this herbal extract has shown that it has the ability to regenerate and revive liver cells and increase white blood cell count.

You’ll want to make sure that your milk thistle supplement contains silibinin because this is a great supplement for histamine intolerance.

Organic sulfur as MSM can cure deficiencies that lead to high histamine levels

Throughout this blog and many others online, we try to push for spreading information about how specific nutrient deficiencies are becoming extremely common for humans living in this generation. Future generations will have to suffer from these deficiencies much worse than us because it is an inherited problem.

The specific minerals that are extremely common today are:

These minerals are in very low quantities in our soils due to the over-use of our soils and agricultural chemicals. This means that our crops are less nutritious and then, so are we because we eat them.

Sulfur is probably the biggest problem for deficiency, especially in first-world countries. This mineral has been proven to support vital immune functions in our bodies.

This may have to do with the sudden skyrocket of severe allergies among newborns, among other contributing factors.

The best way to cure this deficiency INSTANTLY is to take bioavailable sulfur called MSM. This compound is found in all plant and animal cells, being considered the third most important mineral for life.

This is my personal MSM pineal gland and allergy cure method.

MSM crystals for treating histamine intolerance naturally

This MSM crystals supplement is the most effective and inexpensive I could find and it works wonders.

Ever since I learned about sulfur deficiency and MSM supplementation, my allergies have been dramatically reduced. It was unbelievable. I definitely had sulfur deficiency and this was contributing to my allergies and excess histamine levels.

When you supplement with MSM, make sure that the product is a crystallized form of it like this. MSM crystals are much more natural and absorbable for your body. After the first dose of taking MSM (which is the smallest, tasteless, most inexpensive amount) you’ll feel LOADS better with more energy, better physical features, allergies improved, etc.

Will following a histamine intolerance diet help?

Yes, this will absolutely help reduce the amount of histamine in your blood.

If you think that you have severe histamine intolerance, then you should be conscious of your diet because certain foods, even healthy ones, can raise histamine levels and turn out to be an unhealthy food.

Foods in particular that cause histamine intolerance symptoms the most includes:

  • Alcohol: Notably beer, wine, champagne
  • Cooked meat: beef, pork, smoked fish
  • Pickled vegetables
  • Fermented milk foods: yogurt, kefir
  • Aged cheese: Parmesan, gouda, swiss, cheddar
  • Vegetables: spinach, tomatoes
  • Legumes: chickpeas, soybeans
  • Grains: wheat, buckwheat, rye, corn
  • Diamine oxidase inhibitors: alcohol, caffeinated tea and coffee

Following a diet for histamine intolerance will dramatically help you reduce harmful levels in your blood.

histamine intolerance diet

I am always here for you, so if you have a question or something to add about histamine intolerance supplements, please leave a comment below!

Talk to you soon,


Best Histamine Intolerance Supplements for Healing was last modified: November 8th, 2018 by Anthony


  1. Hi Anthony- just found this site and wanted to let you know it was really helpful-one of the best I have seen since researching HIT and I am going to dive in more, and try the supplements you are recommending. So thank you!

    I just saw a comment from someone else in 2017 about immune reactions and menopause and I think that’s what is happening with me. I am peri-menopausal (54) and have been having very bad allergy attacks about two days before my cycle begins. One felt like a hot flash coming on- a flush all over my body, mostly my face, chest and arms. And before I knew it my throat was swelling. The only thing I had had that morning was a cup of coffee. A zyrtec relieved it quickly, but I’m worried about what will happen as I get closer to menopause. The next month I took a zyrtec the week before my period, no attack. The next month I forgot about the zyrtec, and it was an extreme reaction to an intense workout, lying in the sun for 20 min and then a cool shower- and was more of a painful intense itching all over my legs, so painful that I was crying and hyperventilating. Again Zyrtec helped. From what I’m reading the temperature extremes can apparently cause problems with HIT?

    I have had allergies all my life, and been off and on zyrtec, mostly for dust mites and pollen- I think ragweed the most, but have never been tested. But recently with a low carb diet (which has been extremely helpful for my blood pressure, and health, especially my raging hypoglycemia) I have been off anti-histamines for about 2 years and felt finally I had found the way of eating that worked for me. Enter peri-menopause and well, thats all been thrown into a tailspin.
    Turns out, just about everything I am eating is high in histamine! (Especially cheese! I was eating SO MUCH cheese!)
    And now I do see that looking back over the years, certain times of the month I would have what I thought was an achy flu like bug for a few days. Never turned into anything…just a hot feeling with no fever, achy joints, and nausea…I could go to work and function but would be on the couch miserable in the evening thinking the flu was coming or a virus, but it never came. I would call it the “impending illness”.
    And now I’m wondering if it was always a histamine intolerance!
    I also am seeing the signs of HIT coming on more each month and
    I don’t want to go back to another way of eating, so I’m going to try a low histamine diet, at least for a month and then test things, but also try these supplements out.
    Just wanted to share in case anyone else out there in their 40s or 50s is going through the same thing.
    Thank you again for your site!

    1. Author

      Thanks a lot for coming with your experience. It does seem like the histamine block supplement would work because it sounds like you definitely have histamine intolerance, or whatever we describe that as. I hope it works for you and I think it’s likely to be successful. Let me know how things are!

  2. Hi Anthony,
    I have been plagued by giant hives on and off for years. I also have celiac disease (diagnosed 25 years ago), mostly outgrown asthma, an irritable bowel and lactose intolerance.
    Several months ago, I started to have kefir every day, and Kambucha and kimchi several times a week in order to heal my gut. Probiotics seem constipate me and with my
    celiac disease I need to avoid an added cause of constipation. I avoid lactose except for an occasional bit of goat cheese. My diet is a healthy one.
    However, in the last week I have had two episodes of hives, small but hives none the less. I dread the thought of going through another episode of urticaria!
    So I started reading!! And Reading! And found out that all the fermented foods I am eating to heal my gut are increasing my histamine levels! Avocados, strawberries, nuts, white wine, goat cheese all of which are regularly in my diet are also raising my histamine levels. In addition, my blood pressure medication, the dose of which was JUST increased, reduces my natural production of DAO! No wonder my hives are back!! And, no wonder I’ve had to use my rescue inhaler again!
    One article I read said DAO taken just before a meal is NOT absorbed. It, like Lactaid, only breaks down the offending food as it enters the GI tract. If I am avoiding those foods, how does it help if taken rountinely in the absence of those foods.? And should I take it regularly?
    I began taking Claritin when the hives began again but according to what I’m reading, I should not be doing that either.
    Please help!

    1. Author

      Hey, thanks for coming and sharing your experiences. Very interesting, but makes a lot of sense if that’s what you’ve been eating. Also remember too that Lactobacillus strains in probiotics can raise histamine in some people.
      I would take the DAO as needed until it runs out and then you should be able to see if you can function better without it.
      Let me know what u think!

  3. Hi Anthony. So happy to find some guidance on your site. I am still waiting to get into a gastro doc as no one else knows what this is. I suspect Histamine intolerance. I woke up with a bright red face and coincidentally had been using a new soap on my face. The doctor put me on a steroid cream. It cleared it but I now realize it was histamine. My entire face is numb. I then will go red when under any stress good or bad. I was on a low acid diet which leaves high histamine food as supplements. Of a hi histamine food or DAO blocker food list of 22 items, I had been regularly eating 20 of them. I am having trouble with itching and tingling as well. Does this sound like histamine intolerance. I will be checking my probiotics in the am!

    1. Author

      It very well could be! Usually, the itching and redness is associated with high levels of histamine. Let me know what you think!

  4. Hi Anthony,

    I was diagnosed with an autoimmune disease 1 year ago.. I have completely changed my diet since then and feel much better although lately I am having symptoms of oral intolerance and histamine intolerance. I seem to react to most supplements and some foods now as well. I am following the low histamine diet.. and going to start taking a DAO.. but what about sleep. i have severe insomnia b/c i am itchy and my throat swells at night.. do you have any suggestions on how to help this? Otherwise my symptoms seem manageable and are getting better! thanks!!

    1. Author

      Itchy skin seems to be a problem for those that have high histamine levels. The DAO supplement doesn’t help you with that? Also, have you ever taken Zyrtec before? Because the withdrawal symptoms can cause itchiness for months after, especially if you have taken it for a long time.

  5. Does anyone’s ankles swell alot , mine starts the minute spring begins and no one can tell me why. routine labs normal I only take synthroid for hypothyroidism, I have been getting alot of acid reflux/heartburn and fatigue also but the swelling in my ankles really bothers me its been 3 years and seems to be getting worse. It only seems to do it around allergy season with makes me think it might have something to do with Histamine?? any ideas.

  6. Hi Anthony
    I’ve been on Zyrtec since I got pregnant with my son 5 years ago and have been on it since. I tried stopping it a few times and intense itching of the palms of my hands would set in which I attributed to allergies before finally doing some research and finding out Zyrtec has a withdrawal addiction phase of intense itching. I’ve been off the Zyrtec for 2 weeks now. I’ve also been on Advair discus for over a decade. With the help of crocodile bile pills and a Himalayan salt inhaler I was also able to go off of that. After a lot more research after still experiencing intense itching and realizing it was worse after eating a banana I came across the foreign concept of histamine intolerance. I’ve been on quercetin with bromelain by Aller-Pure for a week now. It also contains vitamin C, manganese, fish oil, holy basil, perilla, rosmarinic acid and bioflavonoids. It helps but I’ve come to rely on it as a band aid. I started on this after a horrible bout of allergic pink eye that made my eyes swell shut. I’ve ordered a bottle of ProBiota HistamineX to try to heal and repair my gut to see if that’s the cause of my intolerance. However, after reading your blog I’m considering trying the DAO despite the sticker shock of the product. I’m now experiencing a sever sore throat every evening and waking up feeling as though I’ve come down with a cold and not sleeping at all at night and still having intense itching that seems to travel throughout my whole body. It’s taking all I have to not run back to the Zyrtec and go back to feeling okay at least. The emotional stress it was putting on me is good motivation to never touch the stuff again though and just put out the money for the DAO histamine block supplement. My question is will I have to take the histamine blocker DAO forever? Will I forever have to take the ProBiota? What about Quercetin? I just want to be healthy and not feel like I’m 80 with a giant pill box of things I’m relying on taking every single day the rest of my life. Thank you so much for all your helpful information!

    1. Author

      Hey Brittany,
      No, you will not have to take diamine oxidase forever. I am just suggesting that you try it to compensate for the withdrawal phase when you want to stop taking your OTC antihistamine. The first few days after you start taking it can be very rough because of the influx of histamine in your body. However, the diamine oxidase in histamine blockers quickly breaks it down. You may find benefit from taking it once in a while after your body is finally independent of the antihistamine drug, but quercetin may be a more gentle solution. That’s what I do. Now I keep the histamine blocker for days that I accidentally eat something I am sensitive to and either choose from it or a quercetin capsule if the seasonal pollen is in high amounts. I view supplements as tools that should be taken as needed, rather than addictions. Let me know what you think!

  7. Great article! I was wondering if these supplements are still helpful, especially wondering about DAO, if it’s an HNMT gene we are predisposed to having problems with as opposed to a DAO gene?

    1. Author

      Well, you may or may not have problems with a gene, but supplementing with whatever this enzyme does can act like a replacement. Some people would benefit from the awareness of something like that. Food intolerants and those with histamine intolerance find much benefit from taking them in the short term it seems.

  8. Great info! Im wondering if you think some of these supplements would help me out? I started taking a probiotic with digestive enzymes as well as a magnesium supplement last summer. I felt great initially the first 2 months but then i started to develop allergies-itchy water eyes, runny stuffy nose and nasal passages, puffy face, all so severe. Eventually realized it was from the supplements i was taking. I eliminated both supplements for a few weeks and allergies went away. i reintroduced the magnesium and developed same allergic symptoms so stopped. I reintroduced the probiotic/digestive enzymes as well with allergies developing the second week of use. I tried another probiotic same issues. I have been off all these for a few months and recently saw a naturopath about this. She has me taking high dose vit c, l-glutamine, glutathione, adrenal health and a multivitamin as well as liver detox tea. It has been a couple weeks and im starting to sneeze, puffy face and get these allergic symptoms. Super frustrating. Im trying to understand why my body seems to have a histamine intolerance to supplements. I should add i have been using the multivitamin all along and so i know it is not an allergy to the capsules as they are the same kind of capsule. THe two probitics do have lactobacillus strains. Any ideas?

    1. Author

      That’s an interesting situation. I am not sure why a naturopath would recommend that type of supplementation. It just seems pretty ineffective as if it isn’t treating anything. Perhaps he thinks that this method will provide a deep cleanse? If that is the case, then I would consider if these symptoms are just from the detox. I know that people take high doses of vitamin C with glutamine and liver detox to help flush out stored poisons from the liver, as well as kill flukes present in the liver and lungs. Both of these mechanisms can cause detox reactions that are similar to yours. I would reduce the dose no matter what and watch to see if your symptoms improve. If they do, then this might mean that your body is healing. That’s only one scenario though. You might also be allergic or intolerant to the supplements. Please contact your doctor with your concerns and reply back with what you think! Thanks for visiting.

  9. Hi Anthony, your website has been a life saver for me and I thank you for your hard work in doing the research and sharing with others. I came across your website while researching Zyrtec withdrawal. I have been using Zyrtec for about 6-7 years. I thought I needed it for allergies due to the severe itching until I realized the Zyrtec was causing it! I tried multiple times to quit and just couldn’t bear the itching! I found your website and decided to order the seeking health histamine blocker and this was the first time I have had success. I am now 8 days free of Zyrtec and this supplement has been amazing in reducing the itchiness to a bearable amount. I am curious to know what your recommendations would be on how long to use this supplement or if I should combine it with some of the other supplements you mentioned. There are times that the itching becomes somewhat difficult to deal with and I feel like it’s been harder to tolerate it this week as compared to the first initial days. Ultimately I want to work towards healing my allergies once I pass the withdrawal phase of Zyrtec; I just want to make sure I don’t make the mistake of replacing Zyrtec with a supplement to use every day. Any advice you have would be appreciated. I have to make it through this withdrawal Zyrtec!

    1. Author

      Hey Christina,
      Thanks for visiting! Yeah histamine blocking will be great for you while you try to get off of an antihistamine. I feel like everybody has success with diamine oxidase. To heal your body of allergies, you have to target the certain nutrient deficiencies that you have as well as the hidden infections. Then, your body will never have symptoms or frequent illness again.

  10. Great info! I’ve been dealing with “allergies” all my life, but 4 years ago it got out of control (after a traumatic event). HI and Mast Cell issues are hard won but I am feeling much better these last 2.5 years. I’ve learned I am genetically predisposed to HI (MTHFR, DAO, PEMT, MAO, NAT2…) I have issues with Methyl donors so Quercetin has to be kept in small doses. MSM made me real bad (anxiety/hives, but I also have CBS mutations). Probiotics I’ve loved are GutPro and Custom Probiotics D-Lactate Free. If someone is ultra sensitive they can start with Custom Probiotics L. Rhamnosus (single). Never took DAO supplements (I don’t like the excipients in them, I also don’t do pork). Adaptagens are nice – keep stress and cortisol in check – which both release histamine. For us ladies, hormone testing is imperative! Especially pre menopause. I suggest DUTCH testing. Always so much to learn and it’s so bio-individual. Thanks for sharing what you’ve learned. Always helpful to share and learn from each other 😁

    1. Author

      Thanks for such an in-depth piece of insight! Very interesting and useful advice.

    2. Hi Stacey. Very informative comment! I was wondering if you could elaborate on some of those acronyms, and if they were obtained via specialty testing such as 23 and me, etc.?

      Like so many others in this boat, I’m acting as my own advocate and ‘private investigator’ when it comes to tracking down the culprits and sources of all of my mysterious “allergies”, and pretty much at the beginning of my mission, so any further insights would be greatly appreciated!

      (and Anthony – if you’re able to add anything that would be fantastic – thanks!)



      1. Author

        I’m not sure about some of those acronyms myself. I do know that DAO is diamine oxidase, which is produced by our immune system to help break down histamine. It does this to relieve the inflammation that it causes over time. I think that diamine oxidase is the best supplement you can take for histamine intolerance.

  11. My symptoms sound like Sara’s… but swollen lymph nodes by ear, puffy raised itchy eyelids and under my eyes. And it starts to breakout into this hives type thing when drinking wine or beer. No food just alcohol. It will be itchy and red and hot when it is starting to happen. So I’ve heard milk thistle is the best for this. It could be a liver issue with the histamines

    1. Author

      Milk thistle is a very popular supplement, especially for liver health. However, I think DAO is the best supplement for histamine intolerance if it is a problem for you. Quercetin would be a distant second as well. Milk thistle never worked for me and especially not my allergies. But everybody is different, I guess. But diamine oxidase will work for all people to lower inflammatory histamine levels.

  12. Great article. I may try the MSM and DAO. I’ve been on quite the journey with what looks like histamine intolerance, mast cell activation and possibly a silacylate Intolerance also. Do you know much about silacylate issues?

    1. Author

      Diamine oxidase is the best supplement you could take. It’s a little bit pricey, but you can find something that’s really worth it for histamine intolerance. DAO supplement makes a world of different for some people. I am acutely aware of salicylate allergies, perhaps you could tell me more? Is it just a chemical sensitivity or can it be an allergy as well?

  13. Anthony, I started getting symptoms 2 years ago I believe from pre-menopause. All of a sudden I would get swollen eyes. Overtime it got worse. I could eat and drink anything before so trying to figure it out took a long time to figure out. Since then, My diet is really restrictive so its not so much the food its beer, wine and champagne only. And I’m a light beer drinker. I’m going to purchase the diamine oxidase to see if this helps me. My question is should I take as directed before every meal? or just when I’m about to drink? Anything you can add would be extremely helpful. Cheers!

    1. Author

      Hey Sara,
      That’s interesting, you think that all of that is linked to histamine intolerance? You should let me know more about your triggers and why you came to that conclusion in the first place so I have a better understanding! I would highly recommend diamine oxidase for histamine intolerance treatment, but I think that it would only be necessary to take when you need it. Before every meal seems like too much. I would say maybe take one at night 3 times a week or as needed, depending on your unique health situation. Let me know what you think!

  14. I had a pric test done and no allergies were found although I have been experiencing allergy like symptoms along with frequent infections , colds, flu, food poisoning and now breathing problems and airway pain, chest pain, bad headaches, sinus pressure etc. for almost a year now. I was tested for Asthma too but they don’t think o have it although I’m still on inhalers and nasal spray as well as antihistamine. I guess my question is can you have allergy symptoms but no actual allergies? Also yesterday immediately after eating dinner (which I now know was high in histamine and so was lunch) My breathing that had been ok for the first time in a month that day came back with a bang and I was struck with a bad migraine headache that lasted all night and all day today which painkillers could not take care of. Does this sound like a histamine problem and is this something my GP should be able to help with or am I better off seeing a natural path about elimation and supplements?

    1. Author

      Hey Lynn,
      That’s a good question, so I guess my perspective is about what allergy symptoms are foundationally. Basically, these symptoms are occurring due to inflammation caused by the chemicals released by your immune system upon exposure to an invader. When the invasion is from something harmless, it is an allergy. If it is something legitimate, it is an infectious pathogen. If your allergy test came out all negative, perhaps it did not consider sensitivities/intolerances which aren’t quite allergies? Was the test full board?
      If it was, then I would question the state of health of your body. Perhaps you have an infection. Intestinal parasites are extremely common for people living in the first world, especially Americans. Some parasites cause allergies and affect your immune system. I have written much about intestinal parasites that cause allergies throughout my site! Let me know what you think!

    1. I’m so excited to find your info. I received my MSM in mail today.
      I was on Zyrtec for many years. Quite certain it played a roll in my HIT. I have been on the low histamine diet for months with minimal results. 2 wks ago I stopped all products (deoderant, shampoos, soaps, lotions ect) and was able to get off the Zyrtec . Horrible withdrwls of itching that is just now subsiding. But I feel like I’m on the right road.
      3 sinus surgeries because of nasal polyps. Many meds that have messed up my system. But I feel very hopeful! I will purchase the other recommendations as well.
      Thank you!

      1. Author

        Hey Carol,
        Thanks a lot for visiting us with your optimism and perspective with trying organic MSM crystals. Unfortunately, Zyrtec is one of the most addictive antihistamines, but I can’t believe that it lasted that long for you. With regards to your low histamine diet, what are you doing exactly? I know that many different factors of our lifestyle can affect levels of histamine in our body. Please let me know how things are working out for you and if your withdrawal symptoms are improving along with your histamine intolerance. These supplements have really worked for me.

        1. Hi Anthony,
          So I have been on the MSM for a little over a week now and doing significantly better. I’m also taking Quercetin as well. I still struggle with some nasal inflammation at times, but nothing compared to what it was. I am off all my asthma meds as well. Amazing!!
          I started with 1/8 tsp and I’m now taking 1 tsp MSM 2x/day. My first couple days on MSM caused achy body, but I increased water intake and I did fine after that.
          As far as my diet I am quite strict with keeping off of histamine foods. If I don’t, my nose gets very stuffed up. I do cheat occasionally with steak or wheat thin crackers. I have not eaten foods with benzoate, coloring, additives or preservatives in a very long time .
          There is nothing in my life style that I feel contributes to higher histamine ie: strenuous exercise, stress ECT.
          I feel like once my gut heals I will do amazing.
          I have not purchase DAO yet, but plan to . Considering the probiotic.
          Also, I wonder how much more if any I need to increase the MSM?
          I have gotten several family members and friends on MSM.
          So thankful!

          1. Author

            Hey Carol,
            It’s great to hear that you are motivated to make changes for your health! I’m sure all of us will be doing what you are eventually, because it leads us towards optimal well-being. Doing all this to lower my histamine levels definitely improves my productivity throughout the day. I would say that DAO is the best supplement for histamine intolerance. I’ve heard that the best DAO supplement is the histamine block and the best price for the quality. As for the MSM, you’ll want to start slowly and then increase to 5,000 mg each day until you finish the entire thing. Trust me, your body will use every bit of it. By the end, a moderate dose of 1g should be great each day. Let me know what you think!

  15. Should there be any concern taking these supplements together or with any other supplements that are not cautioned on the packaging? Thank you.

    1. Author

      Hey Chris,
      That’s a good question, thank you. Regarding the supplements that can be considered nutritional, there should be no interactions that you should worry about. Natural antihistamines for histamine intolerance like quercetin may have a slight effect on your body that may interact with a few medications. I’m not sure of the few in particular, but quercetin is generally known to be a safe combination with others. That’s why it’s incorporated in energy drinks and such. I’d feel safe taking natural histamine intolerance supplements, but you should contact your doctor if you feel anxiety about it. Because even if they don’t know the answer, they should be able to refer you to somebody that does.

  16. These histamine intolerance supplements can really work, especially the probiotics. I had no idea that Lactobacillus is unhealthy for histamine intolerance. Thanks a lot.

    1. Author

      Yes, I made sure to tell my viewers about this crucial information that can easily be left out.

  17. Hi Anthony I’ve been on the menopause for 4 years now and since starting it I keep coming out in red rash all over my body it’s looks like I have been scalded I went to my doctor and showed him he said it was hives and gave me antihistamines for it what I would like to know is what is the cause of it please as I never had it before only when I started the menopause and is it worth asking for a food intolerance test I look forward to your reply thank you

    1. Author

      Hello Angela,
      That seems really interesting. If it started after your menopause, then this rash may have something to do with your hormones changing. I am not sure how scaley skin looks like hives, though? I wouldn’t be too interested in food intolerance testing just yet, unless there is a food that you expect. So how does the antihistamine work for you? Does it do anything for the rash?

    2. Hi Angela, I have the very same thing. I’d be interested in talking to you .


      1. Author

        You have the rash during menopause as well? That seems very interesting, but I’m not sure if it’s an allergy. Perhaps it is an immune reaction that could involve histamine intolerance? Do you think that you have an excess of chemical histamine and it is affecting you in this way?

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