natural supplements for histamine intolerance

Best Histamine Intolerance Supplements for Healing

In Antihistamine Addiction, Natural Products by Anthony25 Comments

natural histamine intolerance supplements

Certain Probiotic Strains Can Cause Histamine Intolerance

Histamine intolerance is a condition that describes high amounts of histamine in your blood. This may happen to you are eating a high-histamine diet or are experiencing reactions from food or environmental allergies. A lot of people learn about having this condition and find much success in taking histamine intolerance supplements that help improve their health and well-being.

In this post for you, I will discuss how certain probiotics can cause histamine intolerance and which supplements are actually healthy for treating this condition.

A few factors may lead to elevated amounts of histamine in the body and one of them may likely be genetics. In some people, specific enzymes that degrade histamine like N-methyl transferase and a mucus enzyme called diamine oxidase.

Deficiencies in this enzyme is likely the root cause of histamine intolerance and the symptoms that you experience with it. In healthy people, histamine levels are quickly brought down at the chemical is broken down by the enzyme. In some, histamine lingers in the blood and causes uncomfortable symptoms.

But certain histamine intolerance supplements can definitely treat the condition naturally and effectively. Many others and I would definitely tell you that once you learn about histamine intolerance and you treat it, you can feel and look so much better.

Histamine Intolerance Supplements to AVOID AT ALL COSTS

First of all, I should feel obligated to tell my viewers something really useful for treating histamine intolerance.

The gut has a huge connection to this condition and your intestinal flora has a huge part in it. In fact, some bacteria labeled as healthy probiotics can raise histamine levels in the body.

Lactobacillus bacteria can raise histamine levels in the body

For some people that suffer from histamine intolerance symptoms, this strain of probiotics can actually produce histamine as a natural form of protection. Lactobacillus can actually be considered an animal product because it is formed in milk.

If you are having problems with histamine intolerance, I’d strongly advise you to stop taking any probiotics that contain these probiotics. This is especially if you think that you have adverse reactions to taking them.

This was the case for me. I always thought that taking probiotics was healthy and that Lactobacillus helped my body. Perhaps too much of this bacteria is a very bad thing? More research is always needed.

Effective histamine intolerance supplements that work

These supplements have worked for me and many of you guys. I’m sure they will work for you, but everyone is different and you must find out the root cause of your histamine intolerance.

Hands-down best supplement for histamine intolerance is diamine oxidase

This is the stuff that your body is deficient in, which is causing your histamine intolerance at the source. If you take it, you would be treating the root cause of the condition.

Taking a supplement form of what you are deficient in is exactly what you need.

It is possible that genetics may be to blame for your low diamine oxidase levels, so these people should definitely take a supplement in particular. The best DAO supplement that I could find is this one on Amazon.

DAO for histamine intolerance

This is the best DAO supplement that I could find! Also a great price for the quality.


If you start taking diamine oxidase as a histamine intolerance natural treatment, you can allow your body precious time to heal and restore its natural function of diamine oxidase so that you won’t need to supplement anymore. This is exactly the OPPOSITE of taking an OTC antihistamine, which are all physically addictive and require you to buy more.

And they are very expensive at times. Not to mention that pharma companies likely design these drugs to be addictive so you buy more. The human market can be sketchy, but I usually trust supplements that have been used by our human ancestors for thousands of years.

Histamine intolerance probiotics

That being said about how too much Lactobacillus can be bad for you, definitely start incorporating a quality probiotic supplement that doesn’t have that strain in there.

In fact, Bifidobacterium have been proven in research to benefit histamine intolerance sufferers much more effectively. A supplement with this family strain as a foundation helped high histamine levels tremendously.

histamine intolerance probiotics

This well-reviewed probiotic doesn’t have Lactobacillus, so it would be great for you if you have histamine intolerance symptoms.

This probiotic for histamine intolerance did wonders for my health. I feel much more clear and as if my digestion were much smoother after taking this supplement. Many allergy sufferers review it highly around the world and support its claim to be well-researched and developed.

Organic quercetin is great for lowering histamine levels

This natural flavanol can do wonders for your health. Quercetin has excellent benefits for allergies and high histamine levels because it is a natural antihistamine.

An obvious solution to excess histamine levels would be to take an antihistamine. These types of compounds have a wondrous ability to lower histamine levels in the blood. However, taking an antihistamine from a natural compound, rather than an OTC drug, because it can be naturally processed and assimilated through your body as if it were food.

quercetin as a natural histamine intolerance supplement

The Food and Drug Administration and World Health Organization have stated that quercetin is a harmless and possibly effective supplement.

Personally, this natural antihistamine has changed my severe allergies forever. I no longer need addictive OTC drugs to mask my allergy symptoms for a short while. If you have histamine intolerance, its anti-inflammatory and antihistamine effects can do great things for you.


Milk thistle is an excellent natural antihistamine

The compound in milk thistle called silibinin has been shown in research to prevent the release of histamine and inflammatory cytokines that cause allergies.

This natural supplement targets the mast cells, the immune systems pro-inflammatory cells and blocks the release of inflammatory chemicals that cause allergies.

Most notably, milk thistle as a histamine intolerance supplement can be extremely effective due to its unique immune health benefits. In trials, this herbal extract has shown that it has the ability to regenerate and revive liver cells and increase white blood cell count.

You’ll want to make sure that your milk thistle supplement contains silibinin because this is a great supplement for histamine intolerance.

Organic sulfur as MSM can cure deficiencies that lead to high histamine levels

Throughout this blog and many others online, we try to push for spreading information about how specific nutrient deficiencies are becoming extremely common for humans living in this generation. Future generations will have to suffer from these deficiencies much worse than us because it is an inherited problem.

The specific minerals that are extremely common today are:

These minerals are in very low quantities in our soils due to the over-use of our soils and agricultural chemicals. This means that our crops are less nutritious and then, so are we because we eat them.

Sulfur is probably the biggest problem for deficiency, especially in first-world countries. This mineral has been proven to support vital immune functions in our bodies.

This may have to do with the sudden skyrocket of severe allergies among newborns, among other contributing factors.

The best way to cure this deficiency INSTANTLY is to take bioavailable sulfur called MSM. This compound is found in all plant and animal cells, being considered the third most important mineral for life.

This is my personal MSM pineal gland and allergy cure method.

MSM crystals for treating histamine intolerance naturally

This MSM crystals supplement is the most effective and inexpensive I could find and it works wonders.

Ever since I learned about sulfur deficiency and MSM supplementation, my allergies have been dramatically reduced. It was unbelievable. I definitely had sulfur deficiency and this was contributing to my allergies and excess histamine levels.

When you supplement with MSM, make sure that the product is a crystallized form of it like this. MSM crystals are much more natural and absorbable for your body. After the first dose of taking MSM (which is the smallest, tasteless, most inexpensive amount) you’ll feel LOADS better with more energy, better physical features, allergies improved, etc.

Will following a histamine intolerance diet help?

Yes, this will absolutely help reduce the amount of histamine in your blood.

If you think that you have severe histamine intolerance, then you should be conscious of your diet because certain foods, even healthy ones, can raise histamine levels and turn out to be an unhealthy food.

Foods in particular that cause histamine intolerance symptoms the most includes:

  • Alcohol: Notably beer, wine, champagne
  • Cooked meat: beef, pork, smoked fish
  • Pickled vegetables
  • Fermented milk foods: yogurt, kefir
  • Aged cheese: Parmesan, gouda, swiss, cheddar
  • Vegetables: spinach, tomatoes
  • Legumes: chickpeas, soybeans
  • Grains: wheat, buckwheat, rye, corn
  • Diamine oxidase inhibitors: alcohol, caffeinated tea and coffee

Following a diet for histamine intolerance will dramatically help you reduce harmful levels in your blood.

histamine intolerance diet

I am always here for you, so if you have a question or something to add about histamine intolerance supplements, please leave a comment below!

Talk to you soon,



  1. Great info! I’ve been dealing with “allergies” all my life, but 4 years ago it got out of control (after a traumatic event). HI and Mast Cell issues are hard won but I am feeling much better these last 2.5 years. I’ve learned I am genetically predisposed to HI (MTHFR, DAO, PEMT, MAO, NAT2…) I have issues with Methyl donors so Quercetin has to be kept in small doses. MSM made me real bad (anxiety/hives, but I also have CBS mutations). Probiotics I’ve loved are GutPro and Custom Probiotics D-Lactate Free. If someone is ultra sensitive they can start with Custom Probiotics L. Rhamnosus (single). Never took DAO supplements (I don’t like the excipients in them, I also don’t do pork). Adaptagens are nice – keep stress and cortisol in check – which both release histamine. For us ladies, hormone testing is imperative! Especially pre menopause. I suggest DUTCH testing. Always so much to learn and it’s so bio-individual. Thanks for sharing what you’ve learned. Always helpful to share and learn from each other 😁

    1. Author

      Thanks for such an in-depth piece of insight! Very interesting and useful advice.

    2. Hi Stacey. Very informative comment! I was wondering if you could elaborate on some of those acronyms, and if they were obtained via specialty testing such as 23 and me, etc.?

      Like so many others in this boat, I’m acting as my own advocate and ‘private investigator’ when it comes to tracking down the culprits and sources of all of my mysterious “allergies”, and pretty much at the beginning of my mission, so any further insights would be greatly appreciated!

      (and Anthony – if you’re able to add anything that would be fantastic – thanks!)



      1. Author

        I’m not sure about some of those acronyms myself. I do know that DAO is diamine oxidase, which is produced by our immune system to help break down histamine. It does this to relieve the inflammation that it causes over time. I think that diamine oxidase is the best supplement you can take for histamine intolerance.

  2. My symptoms sound like Sara’s… but swollen lymph nodes by ear, puffy raised itchy eyelids and under my eyes. And it starts to breakout into this hives type thing when drinking wine or beer. No food just alcohol. It will be itchy and red and hot when it is starting to happen. So I’ve heard milk thistle is the best for this. It could be a liver issue with the histamines

    1. Author

      Milk thistle is a very popular supplement, especially for liver health. However, I think DAO is the best supplement for histamine intolerance if it is a problem for you. Quercetin would be a distant second as well. Milk thistle never worked for me and especially not my allergies. But everybody is different, I guess. But diamine oxidase will work for all people to lower inflammatory histamine levels.

  3. Great article. I may try the MSM and DAO. I’ve been on quite the journey with what looks like histamine intolerance, mast cell activation and possibly a silacylate Intolerance also. Do you know much about silacylate issues?

    1. Author

      Diamine oxidase is the best supplement you could take. It’s a little bit pricey, but you can find something that’s really worth it for histamine intolerance. DAO supplement makes a world of different for some people. I am acutely aware of salicylate allergies, perhaps you could tell me more? Is it just a chemical sensitivity or can it be an allergy as well?

  4. Anthony, I started getting symptoms 2 years ago I believe from pre-menopause. All of a sudden I would get swollen eyes. Overtime it got worse. I could eat and drink anything before so trying to figure it out took a long time to figure out. Since then, My diet is really restrictive so its not so much the food its beer, wine and champagne only. And I’m a light beer drinker. I’m going to purchase the diamine oxidase to see if this helps me. My question is should I take as directed before every meal? or just when I’m about to drink? Anything you can add would be extremely helpful. Cheers!

    1. Author

      Hey Sara,
      That’s interesting, you think that all of that is linked to histamine intolerance? You should let me know more about your triggers and why you came to that conclusion in the first place so I have a better understanding! I would highly recommend diamine oxidase for histamine intolerance treatment, but I think that it would only be necessary to take when you need it. Before every meal seems like too much. I would say maybe take one at night 3 times a week or as needed, depending on your unique health situation. Let me know what you think!

  5. I had a pric test done and no allergies were found although I have been experiencing allergy like symptoms along with frequent infections , colds, flu, food poisoning and now breathing problems and airway pain, chest pain, bad headaches, sinus pressure etc. for almost a year now. I was tested for Asthma too but they don’t think o have it although I’m still on inhalers and nasal spray as well as antihistamine. I guess my question is can you have allergy symptoms but no actual allergies? Also yesterday immediately after eating dinner (which I now know was high in histamine and so was lunch) My breathing that had been ok for the first time in a month that day came back with a bang and I was struck with a bad migraine headache that lasted all night and all day today which painkillers could not take care of. Does this sound like a histamine problem and is this something my GP should be able to help with or am I better off seeing a natural path about elimation and supplements?

    1. Author

      Hey Lynn,
      That’s a good question, so I guess my perspective is about what allergy symptoms are foundationally. Basically, these symptoms are occurring due to inflammation caused by the chemicals released by your immune system upon exposure to an invader. When the invasion is from something harmless, it is an allergy. If it is something legitimate, it is an infectious pathogen. If your allergy test came out all negative, perhaps it did not consider sensitivities/intolerances which aren’t quite allergies? Was the test full board?
      If it was, then I would question the state of health of your body. Perhaps you have an infection. Intestinal parasites are extremely common for people living in the first world, especially Americans. Some parasites cause allergies and affect your immune system. I have written much about intestinal parasites that cause allergies throughout my site! Let me know what you think!

    1. I’m so excited to find your info. I received my MSM in mail today.
      I was on Zyrtec for many years. Quite certain it played a roll in my HIT. I have been on the low histamine diet for months with minimal results. 2 wks ago I stopped all products (deoderant, shampoos, soaps, lotions ect) and was able to get off the Zyrtec . Horrible withdrwls of itching that is just now subsiding. But I feel like I’m on the right road.
      3 sinus surgeries because of nasal polyps. Many meds that have messed up my system. But I feel very hopeful! I will purchase the other recommendations as well.
      Thank you!

      1. Author

        Hey Carol,
        Thanks a lot for visiting us with your optimism and perspective with trying organic MSM crystals. Unfortunately, Zyrtec is one of the most addictive antihistamines, but I can’t believe that it lasted that long for you. With regards to your low histamine diet, what are you doing exactly? I know that many different factors of our lifestyle can affect levels of histamine in our body. Please let me know how things are working out for you and if your withdrawal symptoms are improving along with your histamine intolerance. These supplements have really worked for me.

        1. Hi Anthony,
          So I have been on the MSM for a little over a week now and doing significantly better. I’m also taking Quercetin as well. I still struggle with some nasal inflammation at times, but nothing compared to what it was. I am off all my asthma meds as well. Amazing!!
          I started with 1/8 tsp and I’m now taking 1 tsp MSM 2x/day. My first couple days on MSM caused achy body, but I increased water intake and I did fine after that.
          As far as my diet I am quite strict with keeping off of histamine foods. If I don’t, my nose gets very stuffed up. I do cheat occasionally with steak or wheat thin crackers. I have not eaten foods with benzoate, coloring, additives or preservatives in a very long time .
          There is nothing in my life style that I feel contributes to higher histamine ie: strenuous exercise, stress ECT.
          I feel like once my gut heals I will do amazing.
          I have not purchase DAO yet, but plan to . Considering the probiotic.
          Also, I wonder how much more if any I need to increase the MSM?
          I have gotten several family members and friends on MSM.
          So thankful!

          1. Author

            Hey Carol,
            It’s great to hear that you are motivated to make changes for your health! I’m sure all of us will be doing what you are eventually, because it leads us towards optimal well-being. Doing all this to lower my histamine levels definitely improves my productivity throughout the day. I would say that DAO is the best supplement for histamine intolerance. I’ve heard that the best DAO supplement is the histamine block and the best price for the quality. As for the MSM, you’ll want to start slowly and then increase to 5,000 mg each day until you finish the entire thing. Trust me, your body will use every bit of it. By the end, a moderate dose of 1g should be great each day. Let me know what you think!

  6. Should there be any concern taking these supplements together or with any other supplements that are not cautioned on the packaging? Thank you.

    1. Author

      Hey Chris,
      That’s a good question, thank you. Regarding the supplements that can be considered nutritional, there should be no interactions that you should worry about. Natural antihistamines for histamine intolerance like quercetin may have a slight effect on your body that may interact with a few medications. I’m not sure of the few in particular, but quercetin is generally known to be a safe combination with others. That’s why it’s incorporated in energy drinks and such. I’d feel safe taking natural histamine intolerance supplements, but you should contact your doctor if you feel anxiety about it. Because even if they don’t know the answer, they should be able to refer you to somebody that does.

  7. These histamine intolerance supplements can really work, especially the probiotics. I had no idea that Lactobacillus is unhealthy for histamine intolerance. Thanks a lot.

    1. Author

      Yes, I made sure to tell my viewers about this crucial information that can easily be left out.

  8. Hi Anthony I’ve been on the menopause for 4 years now and since starting it I keep coming out in red rash all over my body it’s looks like I have been scalded I went to my doctor and showed him he said it was hives and gave me antihistamines for it what I would like to know is what is the cause of it please as I never had it before only when I started the menopause and is it worth asking for a food intolerance test I look forward to your reply thank you

    1. Author

      Hello Angela,
      That seems really interesting. If it started after your menopause, then this rash may have something to do with your hormones changing. I am not sure how scaley skin looks like hives, though? I wouldn’t be too interested in food intolerance testing just yet, unless there is a food that you expect. So how does the antihistamine work for you? Does it do anything for the rash?

    2. Hi Angela, I have the very same thing. I’d be interested in talking to you .


      1. Author

        You have the rash during menopause as well? That seems very interesting, but I’m not sure if it’s an allergy. Perhaps it is an immune reaction that could involve histamine intolerance? Do you think that you have an excess of chemical histamine and it is affecting you in this way?

Leave a Comment