How Long Does Histamine Last in the Body

How Long Does Histamine Last in the Body?

In Histamine Intolerance Cure by Anthony2 Comments

How Long Does Histamine Stay in the Body?

The simple answer is:

Histamine lasts in the body for 10 minutes to one hour depending on the person. The half-life of histamine has been calculated to be about this long in research subjects and not lasting much longer or shorter for any outliers.

It was very difficult to determine the half-life of histamine due to its short time frame of detectability within the body. Of course, it is also difficult to keep track of it within the body because it’s a natural compound produced by the body’s immune system constantly. When measuring the current levels of histamine in a particular person, it is difficult to keep track of a single histamine molecule because it will get mixed up with newly produced histamine.

However, according to this study, comparing the half-life of tryptase and measuring how long it lasted in the body with histamine as a pair, the duration of time that histamine lasts in the body was thought to be determined. It seems that the length of time is different for each person, though. Perhaps everybody’s unique state of health and genetics affects how long histamine is present in the body.

How Long Does Histamine Last in the Body

How Long Do Histamine Reactions Last?

This is a common question, so I’m suggesting that it means “how long do the effects of histamine’s compound last?” Even if all of the histamines are out of your body, you will still experience the residual inflammation that it has caused before it left. Therefore, you need to consider how long inflammation itself lasts.

A question like this is a very good one, but unfortunately, research hasn’t considered this important subject enough. There isn’t much incentive to perform a broad health study like this and it may be complicated to determine in itself, yet alone classify the type of inflammation that histamine causes in the body. Perhaps there are multiple types of inflammation caused by histamine depending on where it is in the body. Again, it may be different depending on the type of person, just as determined by the 10-60 minute range that histamine as a compound was concluded to last before degrading.

It wouldn’t be a similar method to determine the answer because inflammation doesn’t have a half-life like histamine does and it is not a compound. In fact, inflammation is more of a condition that can lead to many other conditions. Many believe that inflammation is the root cause of all diseases and disorders.

In my opinion, inflammatory reactions caused by histamine will differ in duration depending on how healthy you are. It all comes down to your own body’s ability to heal itself and that is exactly what it has been designed to do by nature and evolution.

The factors that may influence how long inflammation lasts include your unique nutritional diet and if you have any deficiencies, as well as your genetics and lifestyle. By lifestyle, I mean that people who abuse harmful substances like drugs and those who accidentally expose themselves to poison and pathogens like mold that could affect your ability to heal quickly.

Histamine Half Life and Duration of Intolerance

What Does This Mean for Allergies and Histamine Intolerance?

If everybody’s histamine half life is under an hour, this could suggest that the effects of histamine intolerance and allergic inflammation can last this long for any given amount released in the body. To better explain, the histamine being released in one moment will only produce inflammation for under an hour, but this doesn’t mean that the inflammation only lasts for an hour.

Your body could produce more and more histamine if it feels that it needs to. Therefore, histamine intolerance reactions and allergies could possibly last indefinitely, but that’s not usually the case for most people.

There are distinct differences between the roles of histamine within allergic reactions and histamine intolerance. When you have histamine intolerance, your immune system is usually reacting to the histamine absorbed from the food that you eat (food contains histamine that your body absorbs just like nutrients).

It’s not exactly that your body is producing histamine in response to something, but more like the effects of the absorbed histamine are stronger because it is directly affecting your digestive system physically. In people who lack this intolerance, something allows them to be free from the inflammatory effects of histamine absorbed from the food they eat. Perhaps this has something to do with everybody’s unique levels of diamine oxidase in their bloodstream, which is the histamine-degrading enzyme that works to immediately break it down and eliminate it for the purpose of anti-inflammatory effects.

This concept could prove to be a breakthrough when studying allergic reactions that involve histamine. However, I cannot see how funding would be available for studies like these and the incentive to perform something like this might not be great enough for potential researchers. That’s probably because studies are constantly funded by companies (like OTC antihistamine companies) to bribe them to produce the results that they want to see. This science won’t necessarily be true, but the data analysis that they skew cannot really be disputed unless another independently wealthy researcher decides to invest his own money to just prove the other study wrong.

If we could get money out of science, we could definitely start making progress on subjects like these.

Can You Try to Stop Histamine Reactions Faster?

This is where medicine and technology comes in. The compounds produced by our body are not immune to the nature of chemistry and how molecules affect each other. Substances and medicines can work on histamine to try to block it from being produced, or degrade it with enzymatic reactions.

It seems that more natural approaches to medicine work the best for the long-term health of the sufferer. I could definitely say “take an antihistamine because it blocks histamine and the inflammation it causes” but I know better from experience that every antihistamine drug that I’ve taken has caused me more long-term harm than good. My struggles with Zyrtec addiction and withdrawal will always give me a sort of PTSD.

That being said, something that works very well for my histamine intolerance and high histamine levels is diamine oxidase. This is the natural enzyme produced by your body to try to eliminate high levels of histamine in the body when it is causing too much unnecessary inflammation. It’s great that technology has advanced to a point where we can actually isolate this compound into supplement form so that we can take advantage of its benefits.

Histamine Intolerance and Food Intolerance May Actually Be Diamine Oxidase Deficiency

Perhaps people who have severe allergies and histamine intolerance are simply deficient in diamine oxidase in the first place. This makes a lot of sense because that would mean that these people would have to suffer the course of histamine all the way through until its own half-life degrades itself with time.

Many people with histamine intolerance and food intolerance try diamine oxidase for the first time and find that it completely cures their condition. To me, that is amazing. When I tried it, I had found that I could eat some of the foods that I was allergic to and high-histamine foods didn’t bother me at all. How this supplement works is that it supplies your body with a source of the histaminase enzyme initially in your digestive tract, which breaks down the histamine in food there. But some of it can also be absorbed into your bloodstream to be used elsewhere.

Read more here about what I wrote regarding diamine oxidase and histamine intolerance treatment.

It might not be a miracle allergy cure, but it definitely can provide some amazing benefits to those with histamine intolerance and unavoidable moderate-severe food intolerances.

If you have something to add, a question, or criticism about my analysis of histamine’s half life and how long its effects last in the body, then please leave me a comment with the form below! I love criticism and new ideas because I would genuinely like to find out the truth about all this.

Talk to you soon,


How Long Does Histamine Last in the Body? was last modified: November 8th, 2018 by Anthony


  1. Hello Anthony,

    I believe I suffer from HIT; I have hives, I feel nervous/ anxious some days. I have acid reflux. Doctors I’ve seen say it does not exist. Sometimes I feel nauseous. I’m currently taking Quercetin, and just bought Vit. C and Bromelain. Anything you might recommend. I noticed you said you take Histamine Block; Is that every day before every meal or just when you have symptoms.

    1. Author

      I guess it makes sense for doctors to say that histamine intolerance doesn’t exist because it has an inaccurate name. Whatever is causing these symptoms or condition definitely exists. People eat foods with histamine, or trigger histamine somehow in the digestive system, and your body reacts allergically. The histamine block is a revolutionary supplement with DAO for histamine intolerance. It helps to break down histamine from food and in your digestive tract in general. You should take it with every meal that you suspect could be a trigger for your symptoms. If you are taking probiotics or eating yogurt, avoid them if you have HIT. Lactobacillus probiotic strains release their own forms of histamine, which some people cannot tolerate. Bifidobacterium would be a better fit for you if you benefit from probiotics.
      Let me know what you think!

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